MDM2 and glioblastoma: While this is the case for oncogenes associated with the development of GBM, such as Epidermal Growth Factor Receptor (EGFR) (7p12), Cyclin-Dependent Kinase 4 (CDK4) (12q14), and the human homolog of the Mouse Double Minute 2 (MDM2) (12q15) [2-4], other regions of amplification and/or other relevant genes located within these or other regions remain unknown or incompletely described.