Asp f2 also appears to interact with extracellular matrix proteins such as laminin, and exhibited IgE binding from sera derived from patients with allergic bronchopulmonary aspergillosis (ABPA) and cyctic fibrosis-ABPA patients, but not from sera isolated from A. fumigatus-sensitized allergic asthma (and normal control subjects) [31]. Here, IGHE is linked to allergic bronchopulmonary aspergillosis.