Genetic defects in Rap1a, Rac, or p40phox havenot been reported in CGD [38], however, a dominant-negative mutation in the hematopoietic-specific Rac2 GTPase was identified in an infant with severe neutrophil dysfunction and a predisposition to bacterial infections similar to CGD and leukocyte adhesion deficiency [39]. The gene discussed is NCF4; the disease is chronic granulomatous disease.