Subsequently, by screening a promyelocytic leukemia cDNA library, Volpp et al. (1989) cloned and sequenced a cDNA encoding the 47-kD component of the NADPH oxidase system [28], Leto et al. (1990) [29] cloned a p67phox cDNA while Dinauer et al. [30] reported the structure of the gene for the 22-kD light chain of cytochrome-b558 and its chromosomal location, which served as a foundation for the analysis of genetic abnormalities at this locus in CGD. The gene discussed is NCF2; the disease is chronic granulomatous disease.