Interestingly, when compared with neuroblasts, the neuroblastomas have more genes in common with the self-renewing neural stem cells (535 versus 145), among others the neurogenesis genes ASCL1, GSS, STAT3, UTP11L, ENAH, APBB2, CDK5RAP2, and LARGE. The gene discussed is ASCL1; the disease is neuroblastoma.