The immunohistochemistry results on day 16 after BP treatment showed a decrease in Ki-67 protein expression, an increase in cleaved caspase 3 protein expression and an increase in apoptosis in tumor cells relative to the control group in vivo (Fig. 4c); these results are similar to those shown in the subcutaneous RG2 tumor model. The gene discussed is CASP3; the disease is neoplasm.