As CD is characterized by autoimmune injury in different tissues [2,4], we next compared the celiac peptide sequence with human proteins in a protein data bank (Swiss-Prot database of known human sequences) using the BLASTP via the NCBI BLAST network service, and found that the peptide shared a high degree of homology with different self-antigens, including tTG, HSP60, MTMR2 [29], and TLR4 (Figure 2A). This evidence concerns the gene TLR4 and Cowden disease.