In addition to the above cases that were taken directly from rSNP_Guide database, from two recent publications we examined the non-coding SNPs (three in total) within or around two genes, namely INSIG2 [65] and TCF7L2 [66], that represent extremely rare examples of variants associated with complex disease (obesity and diabetes respectively in this case) that have been validated across diverse and multiple human cohorts. This evidence concerns the gene TCF7L2 and obesity due to melanocortin 4 receptor deficiency.