Although elevations of C-reactive protein (CRP) serum levels in newly diagnosed patients with myeloma bone disease have been consistently associated with a poor prognosis (Bataille et al, 1992; Tienhaara et al, 1994; Durie et al, 2003) the significance of preoperative CRP levels have not been clarified as of prognostic importance in myeloma patients, yet, and was, for the first time, subject of this study. This evidence concerns the gene CRP and plasma cell myeloma.