CRP and plasma cell myeloma: In addition to the prognostic value of baseline biological markers including high levels of β2-microglobulin (B2-M), lactate dehydrogenase (LDH), and serum albumin (Bataille et al, 1992), elevations of serum C-reactive protein (CRP) have been consistently associated with a poor prognosis in myeloma (Tienhaara et al, 1994; Kaneko et al, 2002; Terpos et al, 2003).