By contrast, it has been reported that inactivation of the PPARδ gene results in reduced tumorigenicity and in vivo growth of HCT116 colon cancer cells (Park et al, 2001) and that a specific PPARδ agonist enhanced in vivo growth of intestinal adenoma of Apcmin mice (Gupta et al, 2004). Here, PPARD is linked to malignant colon neoplasm.