These findings are consistent with the recent reports that PPARδ mRNA is overexpressed in more than half of CRCs (Yang et al, 2006) and that PPARδ protein expression is elevated in adenomas in Apcmin mice and in colon tumours familial adenomatous polyposis patients (Knutsen et al, 2005). Here, PPARD is linked to Familial adenomatous polyposis.