We believe that the latter findings do not represent nonspecific binding of the PPARδ antibody in tissue samples; β-catenin staining in the same tumour series indicated that cytoplasmic PPARδ was selectively induced in CRC cells, possibly as a result of aberrant accumulation of oncogenic β-catenin (data not shown, our unpublished data). The gene discussed is PPARD; the disease is colorectal carcinoma.