RZG has been shown for instance to reduce the expression/activity of MMPs in a PPARγ-independent manner in adrenal (Ferruzzi et al, 2005) and pancreatic tumour cells (Farrow et al, 2003; Galli et al, 2004) and to increase the expression of TIMP-1 in breast cancer cells (Liu et al, 2003). This evidence concerns the gene PPARG and breast cancer.