Mice deficient for Cx43 exhibit delayed ossification of the calvarial bones and craniofacial abnormalities [28], but more importantly, mutations in GJA1 (the gene coding for Cx43) in humans are responsible for oculodentodigital dysplasia (ODDD), a syndrome that is characterized by defective craniofacial development and digit formation [16]. The gene discussed is GJA1; the disease is oculodentodigital dysplasia.