CDH1 and intraepithelial neoplasia: Given these observations (Fig. 6B, D, F), as well as the recent study by Davis and Reynolds [37] of embryonic SMG epithelial dysplasia and E-cadherin deficiency in p120 null mice, it is reasonable to suggest that the lumen-filling cells are completely derived, and the metaplastic stormal cells are at least partially derived, from epithelium.