Since apoptosis is critical for normal embryonic development and for homeostasis in adult tissues, cancellation of this process with increased resistance to cell death is a common feature of malignant cells and represents a significant obstacle to therapy of human cancers [12,13], some of the identified β-catenin/TCF directed or indirected target genes may represent excellent targets to limit tumor growth. This evidence concerns the gene HNF4A and neoplasm.