IL6 and endothelial dysfunction: Moreover, abdominal adipocytes are an important source of proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) [27], that can reduce the expression and activity of the eNOS in human cultivated umbilical endothelium cells [28] which suggests that this could be one of the mechanisms by which abdominal obesity is related to endothelial dysfunction [29].