For example, SIV-infected genome contains upregulated aldehyde dehydrogenase 5 family member A1 (ALDH5A1, ID: H06676); and concurrent down regulated succinate dehydrogenase complex, subunit D (SDHD, ID: AA035384) and nephropathic cystinosis (CTNS, ID: W94331). The gene discussed is SDHD; the disease is nephropathic cystinosis.