KMT2A and acute myeloid leukemia: Notably, SET was described as part of a fusion gene with the nucleopore complex protein CAN in a patient with t(6;9)(p23;q34) acute myeloid leukaemia (AML) (Adachi et al, 1994), and it was found associated with the oncoprotein Mll (ALL1, HRX) in leukaemic cell lines (Adler et al, 1997).