Recent studies using antigens coupled to antibodies directed against the mouse DC antigen DEC-205 (Steinman and Pope, 2002) or attraction of DC to the tumour via retrovirus-mediated expression of the DC-attracting chemokine CCL20 (Furumoto et al, 2004) illustrate the possibility to directly load tumour antigens onto DC in vivo. Here, CCL20 is linked to neoplasm.