HMGCR and coronary artery disorder: The Prevention of Coronary Sclerosis (PCS) Study was designed as a single-center study to assess the effect of treatment with the HMG-CoA reductase inhibitor pravastatin on the progression and regression of angio-graphically documented coronary atherosclerosis in patients with CHD.23,24 The aim of the present study was to investigate the association between statin-therapy and cancer incidence in the subjects of the PCS Study.