De Ketelaere et al. reported that a short variant form of TWEAK (sTWEAK), unlike full-length TWEAK, was internalised in an Fn14-independent manner and colocalised with glycogen synthase kinase-3β (GSK-3β), one of the target molecules for the PI3K-Akt pathway in neuroblastoma cells [20]. Here, TNFRSF12A is linked to neuroblastoma.