MAPT and frontotemporal dementia: However, several recent studies have demonstrated that the most common pathology associated with clinical FTD is the presence of dystrophic neurites and neuronal cytoplasmic inclusions in the cerebral cortex and hippocampus that are immunoreactive for ubiquitin (ub-ir) but negative for tau, synuclein and intermediate filament proteins (FTLD-U) [4,5].