The total dataset analyzed in this study (354 cases and 372 controls) had the power to detect an effect size or odds ratio greater than 1.6; therefore, if the IDDM8 region conferred a risk similar to that of PTPN22 in RA (odds ratio = 1.8), then we would have had 80% power to detect it (p = 0.05). Here, PTPN22 is linked to rheumatoid arthritis.