PLAU and neoplasm: In a Cox-multivariate regression analysis, only tumor size (p = 0.05), age categories (p = 0.04), and PAI-1 mRNA expression (p = 0.0003) are of prognostic value for BCS while number of lymph nodes, histological type, histological grade and uPA expression did not add any significant independent prognostic value (Table 4).