In a Cox-multivariate regression analysis, only tumor size (p = 0.05), age categories (p = 0.04), and PAI-1 mRNA expression (p = 0.0003) are of prognostic value for BCS while number of lymph nodes, histological type, histological grade and uPA expression did not add any significant independent prognostic value (Table 4). The gene discussed is SERPINE1; the disease is neoplasm.