Nothing has been published thus far about SNPs for MMP-8 and cancer, but three MMP-8 promoter haplotypes (MMP-8–799C>T, MMP-8+17C>G and MMP-8−381A>G) have been found to be associated with preterm rupture of membranes in delivery, indicating a functional role on MMP-8 expression (Wang et al, 2004). The gene discussed is MMP8; the disease is cancer.