The major toxicities observed in >50% of patients during all cycles evaluated for this report included rash, nausea, anorexia, fatigue, ALT elevation, AST elevation, lactate dehydrogenase elevation, leucopenia, neutropenia, lymphopenia, hematocrit decreased, haemoglobin decreased and erythropenia (Table 3). The gene discussed is GPT; the disease is lymphopenia.