However, from 4.5 years after the last surgery, the serum level of CA-125 had gradually elevated to 140.5 U/ml and the CT scans demonstrated newly developed asymptomatic single tumor growth (25 × 20 mm) on the right deep inguinal node (Fig. 3), though no evident tumor was found anywhere else in the body. Here, MUC16 is linked to neoplasm.