We show here that unlike chemotherapeutic drugs, Doxorubicin, Cisplatin, Etoposide or Taxol which up-regulate the cell surface expression of TRAIL-R2 in NB cells [19], HDACIs did not influence any of TRAIL-R1, TRAIL-R2 and TRAIL cell surface expression in NB cells, indicating that sensitisation to TRAIL-induced apoptosis by HDACIs occurs at least partly by different mechanisms. The gene discussed is TNFSF10; the disease is neuroblastoma.