HDACIs can also synergise with TRAIL to induce apoptosis by various mechanisms depending on tumour types, such as increased expression of TRAIL-receptors and TRAIL [24-28], decrease in c-FLIP [24,26,29], Bcl-xL [30], XIAP and Bcl-2 expression (or activation) [31], or increased formation of the DISC [26,32]. The gene discussed is BCL2; the disease is neoplasm.