Resistance to TRAIL-induced apoptosis in various tumours was described to be caused by the deregulation of diverse signalling molecules such as down-regulation of TRAIL-receptors, caspase-8, caspase-10 or Bax, or over-expression of c-FLIP, Bcl-2, Bcl-xL or survivin [12]. This evidence concerns the gene BCL2 and neoplasm.