They include Akt and the target of rapamycin (TOR) that are downstream effectors of the tumor suppressor phosphatase and tensin homologue deleted on chromosome ten (PTEN)-regulated phosphoinositide-3 kinase (PI3K) signaling pathway, implying a link between PI3K signaling pathway and pathogenesis of AD and tauopathies [25-28]. Here, AKT1 is linked to tauopathy.