Together with the previous observation that tau is heavily phosphorylated at Ser214 in NFTs concomitant with decreased levels of PTEN in AD brains [25,43], our current results support the notion that Ser214 phosphorylation may be a crucial factor contributing to tauopathies, which can be affected by PTEN through the PI3K signaling pathway. The gene discussed is MAPT; the disease is tauopathy.