FHIT and cancer: For the other loci, aberrant methylation was not indicated in any of the three cancers because methylated alleles were present in both tumor and normal DNA (i.e. methylation occurred in that particular gene in both tumor and normal tissues) e.g. FHIT gene (Figure 2), or methylated allele was not detected in both (i.e. methylation did not occur in that particular gene in both tumor and normal tissues) e.g. ALX3 gene (Figure 2).