Four loci including DAPK, MGMT, p16 and PTEN were selected for methylation analysis in 127 cervical cancers; APC, CDH13, p16 and hMLH1 were examined in 60 endometrial cancers; and BRCA1, p14, p16 and PTEN in 49 ovarian cancers. The gene discussed is APC; the disease is endometrial cancer.