Among the up-regulated genes in colorectal cancer, we found 14 genes involved in signal transduction (TDGF1 and ENC1), transcription (SOX9, MYC, and HGFR/MET), nuclear transport (NUP62, NUPL1, NUP155, KPNA2, RANBP5, CSE1L/CAS, NTF2, and RANBP1) and cellular transport (SLCO4A1). The gene discussed is RANBP1; the disease is colorectal cancer.