Finally, Brekelmans [39], who has enrolled 1198 women characterized by BRCA1/2 mutations or by a BC risk over 15% between 21–70 years of age in a screening program, found 35 cancers (31 invasive and 4 DCIS) after a median follow-up of 3 years. This evidence concerns the gene BRCA1 and ductal breast carcinoma in situ.