Consistent with the onset of pituitary adenomas in HMGA2-transgenic mice, we have found the induction of HMGA2 expression in human prolactinomas in association with amplification and/or rearrangement of the gene [20], and, recently, we have shown that also the majority of NFPAs express HMGA2, but, in these cases, it is not associated to over-representation of the HMGA2 region [21]. Here, HMGA2 is linked to pituitary gland adenoma.