In the BRCA2-positive family that was missed with both the selection combinations ‘Frank ⩾16 or Gilpin ⩾16 or one of the additional criteria’ and ‘Frank ⩾16 or Evans1 ⩾12 or one of the additional criteria’, the index case had developed breast cancer at age 68. The gene discussed is BRCA2; the disease is breast carcinoma.