IGF2 and neoplasm: A total of 25 (71%) tumours showed alteration of IGF2/H19 or KIP2/LIT1 or both of the domains, of which 10 showed LOH, 11 showed IGF2 LOI only, one showed DMR-LIT1 hypomethylation only, and three showed both IGF2 LOI and DMR-LIT1 hypomethylation (Table 1).