Chromosomes 1p, 4q, 7p, 11q, 14q, 16q, and 17p are also frequently lost in Wilms' tumours, and the RASSF1A tumour suppressor is frequently silenced by promoter hypermethylation (Ehrlich et al, 2002; Harada et al, 2002; Wagner et al, 2002; Yuan et al, 2005). The gene discussed is RASSF1; the disease is neoplasm.