The results of deletion analysis suggested that, in all cases without exception (Fig. 3b to 3e), including those not shown here, the various nutritional and chemopreventive anti-cancer agents activated proximal 5'-upstream region (-1797) of p27 gene at least through -575 p27 (5'-untranslated region (5'UTR) of p27 gene). The gene discussed is CDKN1B; the disease is cancer.