Despite some controversy regarding the involvement of FHIT in oncogenesis there is mounting evidence to suggest that it is more than a passive actor, although the nature of its role in differing cancer scenarios subtypes remains to be elucidated. FHIT is altered in a wide variety of tumors, mostly by genomic deletions and/or promoter hypermethylation, which results in inhibition of the FHIT product. Here, FHIT is linked to cancer.