The same pattern of expression degree was observed in acute myelogenous leukemia (higher for dnmt3b, followed by -1 and then -3a) [28] and breast carcinomas [29]; nevertheless, in the acute phase of chronic leukemia dnmt3a predominates over -3b and -1 [28], whereas in acute lymphoblastic leukemia dnmt1 expression level was higher than -3a and -b [30]. Here, DNMT3A is linked to chronic leukemia.