TLR2 and leprosy: The R753Q polymorphism in TLR2 is linked with reduced response to peptides from Borrelia burgdorferi and Treponema pallidum, and may predispose to Staphylococcal infection or tuberculosis (Ogus et al, 2004) while the R677W polymorphism in TLR2 which impairs activation of NF- B by Mycobacterium leprae and Mycobacterium tuberculosis apparently enhances susceptibility to leprosy and tuberculosis (Cook et al, 2004).