IKBKB and colon carcinoma: Conversely when IKK2 was specifically deleted in myeloid cells, the chemically induced colon carcinomas were reduced in size leading the authors to conclude that, in enterocytes, IKK2 contribute to tumour promotion by suppressing apoptosis, whereas IKK2 KO in myeloid cells leads to downregulation of proinflammatory, tumour-promoting mediators.