Patients with RA exhibited increasing IFN-γ (24 hours: 73 ± 10 pg/ml; 48 hours: 670 ± 242 pg/ml; 72 hours: 1,867 ± 596 pg/ml) as well as IL-10 synthesis (24 hours: 21 ± 13 pg/ml; 48 hours: 166 ± 68 pg/ml; 72 hours: 240 ± 72 pg/ml). This evidence concerns the gene IFNG and rheumatoid arthritis.