High concentrations of EPI or NE (10-5 M) significantly inhibited IFN-γ production in HDs (baseline values of IFN-γ: HDs 3,461 ± 960 pg/ml; patients with RA 2,117 ± 568 pg/ml; p = 0.396) (Figure 1a). This evidence concerns the gene IFNG and rheumatoid arthritis.