PSME3 and neoplasm: We also evaluated in a subcutaneous HT-29 colon xenograft model in nude mice the oncolytic activity of the viruses Ad.Ki•COX, Ad.COX•Ki and dl327. The key findings were: First, intratumoral injections of replication-competent adenoviruses resulted in a significant anti-tumor response when compared to untreated animals, confirming that replication-competent adenoviruses have a direct oncolytic activity [39,41].