In the current study, we investigated the associations between functional SNPs in DNA repair genes (xeroderma pigmentosum complementation groups C (XPC), D (XPD), and G (XPG) (involved in NER), and X-ray repair cross-complementing groups 1 (XRCC1) (involved in BER), and 3 (XRCC3) (involved in HRR)) and the clinical response and survival in patients with locally invasive bladder cancer treated with platinum-based CRT to determine the predictive value of the SNPs in patient selection for bladder conservation therapy. The gene discussed is XPC; the disease is urinary bladder cancer.