While this suggestion remains speculative, it may apply to the Group A serrated polyps that show a distinct likeness to the goblet cell variant of HP in which columnar cells are eosinophilic and lack mucin-filled microvesicles and KRAS mutation is frequent (Figure 1E,F).16,25 The literature refers to the concept of ‘traditional’ SA.43 Based on the current findings, it is likely that several mechanisms can account for adenomatous lesions with glandular serration and that ‘traditional’ SA is not a single entity. Here, MUC5AC is linked to hyperplastic polyp.