Patients with uncontrolled diabetes mellitus develop progressive glomerulonephritis associated with SNHL and degenerative retina disease; it has already been confirmed by immunofluorescence that in the kidney and in the retina of these patients RNAm COL4A1 and RNAm COL4A2 are elevated by the activation of a secondary route of glycosylated metabolites.15 Here, COL4A1 is linked to sensorineural hearing loss disorder.