Interestingly, our best single-locus findings were for promoter SNPs (CCL5 -471C>T, CCL14 -649T>A, CCL23 -289A>C), which might affect the relative expression of these chemokines and lead to downstream effects on leukocyte migration to the CNS, and therefore influence MS pathogenesis. This evidence concerns the gene CCL5 and myeloid sarcoma.