The fact that no alleles of the tumor necrosis factor (TNF) and lymphotoxin α (LT) genes, also located at 6p21, differed significantly between MS patients and controls (see Figure 1A) correlated with the lack of strong linkage of TNF/LT haplotypes with DRB1*15(2) [see Additional File 3] and TNFa9 (not shown). This evidence concerns the gene TNF and myeloid sarcoma.