Based on the results presented, several (partially overlapping) subgroups may be identified in the common group of Russian MS patients, depending on carriership of distinct minimal patterns of susceptibility including one (DRB1*15(2) or TNFa9), two (CCR5Δ32, DRB1*04) and three (-509TGFβ1*C, DRB1*18(3), CTLA4*G or -238TNF*B1,-308TNF*A2, CTLA4*G) alleles of candidate genes. This evidence concerns the gene CTLA4 and myeloid sarcoma.