Although a genetic analysis of CSP T cell polymorphisms in individuals exposed to falciparum malaria along the Thai–Burmese border [16] indicated that naturally acquired immune pressure in the human host is unlikely to play any significant role in selecting and maintaining the extensive polymorphisms that occur naturally in the CSP Th2R and Th3R regions, such responses are typically weak and short-lived. Here, DNAJC5 is linked to Plasmodium falciparum malaria.