Positivity for ER, PR, p53, p21, p63, and KI-67 in HUT areas of reduction aesthetic mammaplasty specimens (HUT-ARM), HUT of mammaplasty contralateral to breast cancer (HUT-MCC); HUT adjacent to invasive mammary carcinoma (HUT-IMC), and in invasive mammary carcinoma (IMC). The gene discussed is ESR1; the disease is Merkel cell skin cancer.