We report here: 1) that it is the HGF in stromal-conditioned media that affects C4-2 metastatic prostate cancer cell adhesive behavior, 2) that this action is through the integrins, and 3) that the dose-dependent response of Met-negative C4-2 cells to HGF treatment can be abolished through the addition of antibodies against the nucleolin protein. This evidence concerns the gene HGF and Familial prostate cancer.