Furthermore, transcription analysis in untreated cells suggested the predictive value of expression of both hENT1 and dCK, while, as previously reported in lung and colon cancer cells, a similar correlation was found between TS and chemoresistance to pemetrexed (Sigmond et al, 2003; Giovannetti et al, 2005). This evidence concerns the gene DCK and malignant colon neoplasm.