Finally, although the results should be considered very preliminary and the possible prognostic value of other determinants, such as other intracellular 5′-NT, clearly requires to be evaluated in detail, the present study provides the first evidence of a significant correlation between gemcitabine chemotherapy outcome and hENT1, and dCK expression, in bladder cancer specimens. The gene discussed is SLC29A1; the disease is urinary bladder carcinoma.