Based on the information that Dox can synergise with TRAIL to elicit cytotoxicity in various types of tumours (Hannun, 1997; Los et al, 1997; Keane et al, 1999; Muzutani et al, 1999; Yamanaka et al, 2000; Lacour et al, 2001; Wu et al, 2002) as well as that PL is able to interfere with tumour growth, we tried to explore the potential of the combination treatment of Dox and PL against prostate cancer. The gene discussed is TNFSF10; the disease is prostate carcinoma.