MRPs haveproinflammatory effects in the extracellular milieu [6, 7].S100A12 is detected in the synovial fluid and plasma of patientswith gout, rheumatoid arthritis, and psoriatic arthritis [8],suggesting that S100A12 may be involved in the inflammation inthese diseases. The gene discussed is S100A12; the disease is rheumatoid arthritis.